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Requirements of Vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation

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It acts as a neurotransmitter in the brain, triggers the release of stomach acid for digestion, and serves as a critical mediator in the immune system's defense against pathogens and injury

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doi: 10.1038/s42003-022-03696-z 233 Cardenas-DiazFLOsorio-QuinteroCDiaz-MirandaMAKishoreSLeavensKJobaliyaCet al

The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form