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For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications. The biological basis of GLP-1 resistance is still unknown and is likely complex

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This is often due to: Slower metabolic rate Reduced growth hormone levels Insulin resistance Increased stress and inflammation Lower energy production The body becomes less efficient at burning fat and more efficient at storing it

Supports appetite regulation Acts on GLP-1 pathways involved in appetite, satiety, and digestion

Gua means scraping, and sha is the petechiae that comes up from the scraping

Nutrient optimization comes after GI tolerance is established