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For example, in KRASG12C-driven LC cells, KRASG12C inhibition induces ULK1/2-mediated autophagy as a critical survival mechanism, highlighting its potential as a pharmacological target (17)

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Tirzepatide is typically initiated at 2.5 mg weekly and gradually increased at minimum 4-week intervals through 5 mg, 7.5 mg, 10 mg, 12.5 mg to a maximum of 15 mg based on individual response and tolerability

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The list identifies these drugs for which the agency is working to reduce the impact of the shortage

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