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Notably, over the subsequent 6 days, we observed a sustained body-weight-lowering effect after infusion of GLP-1MK-801, but not semaglutide, suggesting that the targeted inhibition of NMDA receptors in GLP-1 receptor-positive neurons might promote sustained changes to the defended level of adiposity

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The trial also flagged a new dose-dependent safety signal - dysesthesia, an abnormal nerve sensation such as tingling or burning - at 20.9% on the 12 mg arm, which will shape the label and the real-world dose pattern

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They are generally safe for most people, but not recommended for individuals with a history of medullary thyroid cancer, MEN2, pancreatitis, severe kidney or liver disease, or those who are pregnant or breastfeeding. What are the most common side effects of GLP-1 drugs