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The result is a complex mixture of low-molecular-weight neuropeptides and free amino acids all below 10,000 Daltons in size

At the follow-up time points, including one month to 1.5 months to three months to six months to 12 months, there were statistically significant differences in pain reduction scores in favor of PRP

Therefore, a guiding principle emerging is that early intervention in the perioperative timeline (pre- or intra-operative) yields the best chance to alter the trajectory of organ injury

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The Phase II study is expected to read out in mid-2025