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There are several processes which are fundamental to DCM progression that also involve the proteome of the myocardium that will be altered in structure and quantity as a response to the diabetes-induced tissue damage in the heart (111)

The infected mice exhibited a higher increase in interleukin (IL) IL-5, IL-4, and IL-2 than IL-12 and interferon- (IFN-), suggesting an important alteration in cytokine profile from Th1 to Th2 (Figure 2) [38]

Kang, C., Punjani, N., Lee, R

Mol Cell Biochem 39:357368 Thon VJ, Vigneron-Lesens C, Marianne-Pepin T, Montreuil J, Decq A, Rachez C, Ball SG, Cannon JF (1992) Coordinate regulation of glycogen metabolism in the yeast Saccharomyces cerevisiae

A functional role for macrophages was confirmed by depletion studies, in which the removal of macrophage populations, by the administration of clodronate-liposomes reversed the protective effect of the T

Youll also toss and turn and wake up frequently throughout the night