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Lubke JHR & Rollenhagen A (eds.)

While some individuals may begin to feel a difference in their symptoms, such as reduced discomfort from an injury, within a few weeks, the more profound and sustained benefits typically become apparent after a few weeks to a few months of consistent therapy

These include the dopamine 1 receptor (D1R), the dopamine 2 receptor (D2R), the melanocortin-3 receptor (MC3R), the serotonin 2C receptor (5-HT 2C ), and possibly the cannabinoid type 1 receptor (CB1)

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1g) (compared with Gipr AP-GFP mice), RER, energy expenditure or ambulatory activity, as measured in metabolic cages (Extended Data Fig