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e , SMART1 inhibited Smurf1 protein level and PDK1 neddylation in cells (Smurf1-L: 0.5 M, SMART1Et: 0.5 M or SMART1: 0.5 M)

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It also implies that any beneficial effects on vascular or RPE pathology may be mediated indirectly, either through neuronal signaling pathways within the retina or via systemic anti-inflammatory and metabolic improvements