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For patients needing more than semaglutide can deliver, CagriSema is the next step
Reps in Reserve or RIR is the most useful way to gauge this
A benefit exclusion means the drug category is not included in the plan design it is different from a prior-authorization denial
Tolerability concerns were noted in the SELECT study and patient input described side effects as frustrating or distressing, yet generally manageable
Currently, there is no established causal link between tirzepatide use and increased cancer risk in humans
Atrial fibrillation A meta-analysis of 10 RCTs involving 12,651 patients (7,285 on semaglutide [oral and subcutaneous] and 5,366 on placebo) with a median follow-up of 68 months found that semaglutide significantly reduces the risk of AF by 42% compared to placebo (RR 0.58
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