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Long-term metformin therapy and vitamin B12 deficiency: an association to bear in mind

The strongest direct human data on CJC-1295 involve the DAC-modified long-acting analog , not the No DAC version. For CJC-1295 without DAC, the mechanistic rationale is based on the broader GHRH (1-29), sermorelin, and Modified GRF literature. That mechanism is biologically well grounded, but the evidence should still be described carefully

This could be due to a controversial belief that obesity isnt a disease, despite the American Medical Associations 2023 statement recognizing it as such

Ryu et al