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The most practical takeaway is to keep expectations modest and decisions individualized

These results correlated with reduced inflammatory cytokines IL-6 and TNF, upregulation of phase II enzymes associated with co-treatment with sulforaphane (Jazwa et al., 2011)

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While rarely severe enough to cause discontinuation, it is a hallmark of the triple agonist mechanism, likely linked to glucagons influence on sensory pathways or metabolic shifts in the peripheral nervous system