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Cases of remitting seronegative symmetrical synovitis with pitting edema syndrome, presenting as symmetrical synovitis with dorsal hand and foot edema, have also been reported in individuals receiving DPP-4 inhibitors [13, 34]

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The most common are nausea, facial flushing, darkening of moles, headaches, and increased libido

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No study examined tolerance or dependence with extended use, and no study followed a repeated-dosing cohort beyond a few months

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