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This is an active and beginning area of investigation, and the implications for human disease remain speculative pending controlled clinical trials

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This is due to its smaller size and modified structure, which allows it to be more easily absorbed by the body when taken orally

The studies also had some shortcomings, as some only administered fluoxetine at the end of pregnancy and could not assess the effects of the drug throughout the entire pregnancy period, some did not explore the specific mechanisms of fluoxetine-induced fetal acidosis, hypocalcemia, and altered maternal estradiol metabolism, and some failed to assess the maternal and fetal health status over a long-term follow-up period

(2004) 'Vitamin C pharmacokinetics: implications for oral and intravenous use', Annals of Internal Medicine, 140(7), pp