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For any compound that will be used for decades in chronic disease, a dedicated MACE (major adverse cardiovascular events) trial is required

If youre moderately overweight, you might find the side effects intolerable relative to the benefit

If you have Type 2 diabetes, cardiovascular disease, or sleep apnea alongside obesity, your provider should document those conditions prominently

But increased demand may increase prices when they are more widely available

There is enormous exuberance about starting GLP-1 drugs, but not nearly enough attention to what happens when people stop, said senior author Ziyad Al-Aly, MD, a WashU Medicine clinical epidemiologist and chief of the Research and Development Service at the VA Saint Louis Health Care System

For patients, the promise of effective weight loss coupled with health improvements is appealing