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In human narcolepsy patients there is a significant reduction in the amount of detectable orexin A and orexin B as well as an 80%100% reduction in the number of neurons that contain detectable prepro-orexin mRNA

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The Stein Institute for Research on Aging plans to translate these results into individualized aging dashboards to track biological aging with epigenetic clocks, enabling clinicians to design personalized therapies that target the underlying mechanisms of aging and help prevent agerelated diseases

Chronic inflammation Inflammation and metabolic stress can disrupt gut-hormone communication

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