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It also encourages these companies to keep innovating on new, more differentiating drugs that they will be able to sell at higher prices

To do this, payers need to assess the long-term ROI of GLP-1s, including the benefits of reduced spend on high-cost comorbidities

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Findings from some of these models have been difficult to interpret since in certain studies the GLP-1 receptor agonists concomitantly affected glucose homeostasis, which is itself usually associated with reduced kidney injury, independent of the mode of glucose lowering

This can influence blood sugar control after meals

Two or three days early changes the math significantly