Hyperleptinemia is a common feature of obesity, and serum leptin levels are strongly positively associated with the percentage of body fat [346, 347]
In addition to treating the cardiac stresses that occur with obesity and associated morbidities, such as OSA, additional cardiovascular benefits of GLP-1s are thought to be mediated by their action on vascular smooth muscle cells and endothelial cells
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doi:10.1016/j.mce.2020.110835 174
(5) D A Sibarov, A B Volnova, D S Frolov, and A D Nozdrachev (2007) Effects of intranasal administration of epitalon on neuron activity in the rat neocortex Neuroscience and Behavioral Physiology, 2007 Nov, Volume 37 (Issue 9), Pages 889-93
