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The study included 142 residents of Ikaria aged 66 to 91

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PIONEER 1: Randomized clinical trial comparing the efficacy and safety of oral semaglutide monotherapy with placebo in patients with type 2 diabetes

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Interestingly, sustained activation of ROS can trigger various forms of programmed cell death, including apoptosis, ferroptosis, pyroptosis, necroptosis, oxeiptosis, NETosis, parthanatos, autophagy, necrosis and immunogenic cell death [22, 213, 214] (Fig