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Secondly, repeatedly injecting into the same spot can lead to lipohypertrophy (fatty lumps) or lipoatrophy (loss of fat tissue), both of which may affect drug absorption and cause discomfort

The Lancet , 402 (10402), 613-626

Back Montesano, R, Schekman, R, Rothman, J, Perrelet, A (7 Jan 2020) 'In Memoriam: Leilo Orci, 1937-2019', Proceedings of the National Academy of Sciences , 117/1, 15-17