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Recent trials have shown: Up to 20% body weight reduction with weekly GLP-1 agonists (Wilding et al., NEJM) Improvements in HbA1c, fasting glucose, and cardiovascular outcomes (Marso et al., NEJM) This drug class is now widely used for: Obesity (with or without diabetes) Type 2 diabetes PCOS-related insulin resistance Metabolic syndrome Common Side Effects and Patient Concerns Despite their benefits, GLP-1 agonists are not without risks or drawbacks

Notably, this study did not include data specifically addressing early PsO

Both medications have similar digestive side effects, and the better option depends on treatment goals, tolerance, and medical guidance

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Start a fiber supplement before or at the same time you begin GLP-1 medication, not after constipation develops

10.2337/db14-1577 72 ZhaiR.XuH.HuF.WuJ.KongX.SunX