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3.2 Iron dysregulation in modulating ferroptosis susceptibility Iron overload, as a key inducer of ferroptosis, disrupts cellular iron homeostasis by interfering with critical components of iron metabolism at both transcriptional and post-transcriptional levels, thereby significantly increasing cellular susceptibility to ferroptosis ( In IBD, such as UC and CD, accumulation of iron ions has been identified as a key mechanism underlying intestinal epithelial cell damage ( 3.3 Ferroptosis and IBD Acute inflammation constitutes a protective response to infection or tissue injury

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We confirmed that this was the causal mutation by transformation-rescue (Fig