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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

LF reduces serum glycated protein and fasting insulin concentrations and improves hepatic insulin sensitivity (30), and also reduces serum or hepatic levels of TNF-, IL-6, and IL-1, reversing abnormal inflammatory responses in diabetic mice (40), and regulate the expression of cytokines, such as TNF-, IL-6, and IL-1, to exert the protective effect of the intestinal immune barrier (41), rebalance the disorders of glucose-lipid metabolism, and restore inflammatory parameters (42)