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Solvents used were A: 5% acetonitrile in water, 0.2% formic acid

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Furthermore, several metabolites, such as bilirubin and melatonin, have antioxidant effects [60, 61]

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Studies discovered mitochondrial-derived peptide called MOTS-c has been shown to significantly reduce the level of pro-inflammatory factors in mice and increase anti-inflammatory factors and insulin-stimulated glucose treatment rates, as well as glucose homeostasis (79)

Sequencing, data processing, and analysis parameters The study's primary aim was to determine whether 5A-1MQ treatment in combination with a switch from WD to LD rendered the intestinal microbiome comparable to that of mice continuously maintained on LD, and distinct from that of DIO mice switched to LD but given saline injections or mice maintained continuously on WD