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Key features Melanocortin analogue for in-vitro receptor-signalling and SAR studies

The administration of System X c inhibitors can deplete intracellular cysteine, reduce GSH concentration, trigger OS, and increase cell sensitivity to ferroptosis ( Small molecule erastin can directly and selectively target and inhibit the System X c , and irreversibly bind to and inactivate XCT, leading to continuous disorder of cystine uptake, a decrease in cellular antioxidant capacity, and eventually ROS accumulation and ferroptosis (Sato et al., 2018

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Finally, the incidence of short-chain acyl-CoA dehydrogenase deficiency has been reported at ~1:35,000 to 1:50,000 [19, 20]

Diabetes 64, 17861793