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Nie et al., 2022)

However, these compounds are majorly metabolized into TMA by several taxa of the gut microbiota 16,17 in the small intestine, transported through the bloodstream to the liver where they are oxidized into TMAO 18 which subsequently travels to the kidneys to be excreted through the bladder 19 , where it can be converted back into TMA by indigenous or pathogenic bacteria

What are the available data on the use of Wegovy (semaglutide) combined with metformin for weight loss?

Regarding renal health, the medication itself is not nephrotoxic, but the side effects (vomiting, diarrhea) can lead to dehydration, which may injure the kidneys

GLP-1 is a naturally occurring hormone produced in the gut that signals to the brain when you've had enough to eat

Additionally, semaglutide exposure alone decreased proliferation in NEPC cells, which are not sensitive to ARSI (Figure 4)