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While the first studies showing this were in mice [14], human studies have corroborated these findings [200], although its importance in relationship to traditional clearance pathways across the BBB and subarachnoidal granulations has been challenging to quantify

(Fortified is important because it ensures that thiamine levels are adequate.) Again, because excess B vitamins can be excreted, toxicity is extremely unlikely to be incurred

Limited treatment efficacy and low response rates with this combination led to the early termination of the study