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Compare this to oral administration: even if 20% of the dose survives first-pass metabolism, peak plasma levels occur 6090 minutes post-ingestion, and the concentration curve is flatter and more prolonged

doi:10.1172/JCI28898 17

As a result, ferroptosis of cardiomyocytes was inhibited, I/R-induced cardiac injury was reduced, and cardiac function was enhanced [109]

The Q126X mutation in ABCG2 (encoded by SNP rs72552713 ) encodes an entirely nonfunctional ABCG2, and carriage of this allele is a major factor in intestinal (extra-renal) underexcretion of urate with renal uric acid overload (without uric acid overproduction) ( Figure 1 - 5 )

However, the biological plausibility of risk, combined with the lack of long-term human data, demands caution