In vitro studies have shown that intraduodenal instillation of soy protein hydrolysate (SPH) in weaned piglets promotes the release of anorexigenic hormones such as peptide YY (PYY) and glucose-dependent insulinotropic polypeptide (GIP), stimulates insulin production in pancreatic islet cells by elevating the level of GLP-1 to inhibit short-term feed intake and triggers the secretion of cholecystokinin (CCK) in the liver through activation of the CaSR and the intracellular Ca 2+ /TRPM 5 pathway to reduce the appetite of pigs (76)
Lipson, D
Eli Lilly sponsored SURMOUNT-5, (NCT05822830), a Phase IIIb, open label, multi-centre, randomised clinical trial to compare the efficacy and safety of tirzepatide (Zepbound) versus semaglutide (Wegovy) in overweight or obese adults and at least one additional named weight-related comorbidity that was not T2D 24
Always talk to your healthcare provider before starting a new medication
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight Full Text View ClinicalTrials.gov
For Further Reading on "Ozempic Face" Effects of Bariatric Surgery on Facial Features ( Archives of Plastic Surgery ) Facial aging after GLP-1 receptor agonistinduced weight loss: the emerging Ozempic face phenomenon ( Journal of Diabetes & Metabolic Disorders ) Hyperdilute Radiesse Preserves Facial Volume in Glucagon-Like Peptide-1 Receptor Agonist Users Undergoing Rapid Weight Loss ( Aesthetic Surgery Journal Open Forum ) The Bottom Line "Ozempic Face" isn't a mysterious condition
