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Preliminary research also suggests that NAD+ may play a role in supporting sirtuin activity proteins being studied for their involvement in healthy aging

doi: 10.1071/RD11118 124 PersaniLRossettiRDi PasqualeECacciatoreCFabreS

[DOI] [PubMed] [Google Scholar] 46.Moore H-PH, Silver RB, Mottillo EP, Bernlohr DA, Granneman JG

This reinforces the need for carefully titrated regimens, especially in clinical settings where circadian timing (chronopharmacology) may dictate efficacy