Nature 590 , 473479 (2021)
They include - Nausea (the most common one across both) Constipation Diarrhoea Fatigue, particularly in early weeks Unique side effects to the pill - In OASIS 4, vomiting was notably more common with the pill than typically reported with the injection: Nausea: 46.6% (pill) vs 18.6% (placebo) in OASIS 4 Vomiting: 30.9% (pill) vs 5.9% (placebo) - higher than usually seen with the needle version Discontinuation due to adverse events: 6.9% with the pill, similar to the injection Fasting could be the main reason behind the higher vomiting rates
PlexusDx screens for this during intake, and all thyroid patients receive enhanced monitoring schedules
Over the 20th century, additional treatments were developed and FDA approved for treatment of overweight and obesity, including phentermine, phentermine/topiramate, orlistat, and naltrexone/bupropion
This is particularly important for older adults, who are at greater risk of sarcopenia, and for individuals aiming to maintain physical function and metabolic health during treatment
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