DN is pathologically characterized by mesangial matrix thickening, progressive destruction of glomerular and tubulointerstitial, and loss of functioning glomeruli, ultimately leading to chronic renal failure [138, 139]

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Semaglutide: Available as a weekly injection or a daily oral tablet
Ozempic is available at MedBridge WV
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A diferencia de los GLP1-RA, se ha observado en la evidencia clnica que los IDPP-4 no tienen beneficios cardiovasculares en pacientes con DM2 a pesar de contribuir en el control glucmico, por lo que no cumplen con los nuevos lineamientos en el tratamiento de la DM2, donde se busca reducir la incidencia de complicaciones ms all del control glucmico 58