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Recently, new randomized clinical trials with second-generation XOi (febuxostat and topiroxostat) have been initiated [57]

3 Crucially, the same study pointed to a neural, vagally mediated mechanism: the effect had the signature of vagal inhibition rather than a direct action on gastric smooth muscle

The selective vulnerability in females led the authors to hypothesize a role for estrogen-linked mechanisms, although this was not tested

Mirone M, Giannetta E, Isidori AM

Sci Rep 15 , 22940 (2025)

[57] The effects of toxicity can include liver damage, haemolytic anaemia, oxidative damage to the red blood cells and bleeding tendencies