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The earlier phase 3 study tested two doses against placebo, and the results ran the opposite way to intuition: 0.05 mg/kg/day met the primary endpoint (16/35 responders, p=0.007) while the higher 0.10 mg/kg/day dose failed it (8/32, p=0.16) [3]

Incretin-based therapies are associated with acute pancreatitis: meta-analysis of large randomized controlled trials

The drug also contributed to a 94% lower chance of progressing from prediabetes to diabetes compared to placebo

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Most protocols start patients at a low dose, typically 2.5 mg per week, and gradually increase the dosage over several weeks

Plans often paid $60,000 for a course of therapy with no guarantee that the employee would stay with the company