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Notably, the catalytic residue within the active site, Sec (U), is encoded by the nucleotide sequence UGA that also encodes the STOP codon 78,79

Lombardi, L., Oliveira-Pacheco, J

Although the glutathione pool of mitochondria is less than 20% of the total cell GSH, its role in the organelle is crucial to the maintenance of cell homeostasis and to routing disabled cells into apoptotic or necrotic death

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