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Sci Rep 9(1):18409 Sullivan LB, Martinez-Garcia E, Nguyen H et al (2013) The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling

Glutathione offers anti-aging benefits and promotes healthy aging due to its potent antioxidant capacity, which protects cells from damage caused by oxidative stress and inflammation (Weschawalit et al., 2017)

In contrast, in a study aimed to characterize immune responses to mRNA COVID-19 vaccines among NS workers, despite significantly reduced sleep duration in NSW post-vaccination, no differences were observed in antibody titers compared to day workers

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Oxidative stress: impact in redox biology and medicine

While necessary, this phase transforms toxins into "reactive intermediate metabolites" that are frequently more toxic and volatile than the original substance, generating massive amounts of free radicals