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We next examined acyl-CoA abundance, finding that acetyl-CoA is modestly reduced, HMG-CoA is dramatically reduced, and malonyl-CoA tends to be elevated in DKO cells, similar to the phenotype seen in ACLY KO cells in the absence of acetate (Figure 2C

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In AD models, Nrf2 deficiency exacerbates oxidative stress, leading to increased lipid peroxidation and DNA damage, particularly in astrocytes, which accelerates neurodegeneration and inflammation

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