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11 Future Perspectives 11.1 Monotherapy Given the modest weight loss delivered by SGLT2 inhibitors, it is not likely that they will be successful as monotherapies for obesity

Many people expect steady weight loss right away, and when that doesnt happen, it can feel frustrating, or even discouraging

Gupta YK, Ramachandran SS

Good news: A thoughtful, holistic strategy can help counteract these unexpected downsides

However, during APAP overdose, the excessive production of NAPQI overwhelms the cellular antioxidant capacity, leading to the accumulation of NAPQI-protein adducts