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APS is then phosphorylated by an APS kinase (SD) to form 3-phosphoadenosine 5-phosphosulfate (PAPS) followed by sulfite release from PAPS via the PAPS reductase SA

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Because of this detoxification process, cyano B12 could potentially deplete glutathione (GSH), an important antioxidant that helps decrease lipid peroxidation associated with oxidative stress