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For long-term use, serum copper and ceruloplasmin would need monitoring, and gene expression effects evaluated since GHK can downregulate overexpressed cancer-associated RNAs

However, elevated SOD activity was observed in some patients (171), which points to an adaptive response to ROS overproduction

Previously, it has been reported that senescent cells accumulate iron, and this might correlate with an elevated expression of the transferrin receptor (TFRC) and the light and heavy chains of ferritin (FTL and FTH1) 48,49,50

Feb 8 1988;228(1):179-181

doi: 10.1126/science.abj3986 243 GoehlerLEGaykemaRPHansenMKAndersonKMaierSFWatkinsLR

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