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Deleterious off-target effects in women 10 years or more past menopause, such as ovarian, endometrial, and breast cancers, intravascular thrombosis, cardiovascular episodes, and stroke, and suppression of endogenous testosterone and libido and increased risk of prostate cancer in men, have precluded broad clinical applications (Anderson et al., 2004
In this latter case, the vasodilation effect was far greater than that in the former
GoodRx, a platform for medication savings, shares what you should know about oral semaglutide (Wegovy) for weight loss how it works, how to take it, and more
As Bellomo put it, The evidence is approaching the threshold where practical planning should begin in earnest, even as we await data on sustained real-world outcomes. GLP-1 medications may ultimately become an important driver of cardiometabolic health improvement, but translating clinical promise into measurable mortality experience will take years of real-world data
Lancet Psychiatry
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