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Regarding our findings on the direct mitochondrial actions of Rot, it is essential to consider that mitochondria form a heterogeneous and compartmentalized population that adapts to local cellular demands, a phenomenon particularly pronounced in neurons 97

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doi:10.1016/j.oret.2024.12.006 25

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Apoptosis and necroptosis in the liver: a matter of life and death

DHvR has acted as a consultant and received honoraria from Boehringer Ingelheim and Eli Lilly, MSD, Novo Nordisk, and Sanofi and has received research operating funds from Boehringer Ingelheim-Eli Lilly Diabetes Alliance, MSD, AstraZeneca, and Novo Nordisk