At the same time, pro-inflammatory factors (TNF- and IL-1) were downregulated and anti-inflammatory factors (Arg-1 and IL-10) were upregulated due to SIN produced through the NF-B pathway, which decreased M1 macrophage levels and increased M2 macrophage levels
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Downregulated in HCC 31,32,33 , HNF4 is considered as a tumor suppressor that represses the development of HCC and inhibit epithelial-mesenchymal transition (EMT), a process that promotes cancer progression and metastasis 34,35,36
DNA Replication and Gene Expression
doi: 10.2165/11534750-000000000-00000 19 LipskaKJBaileyCJInzucchiSE
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