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Only then can the cobalt atom be reduced from an oxidative state of +3 to the biologically active +1, forming methyl B12 in the cytosol, and adenosyl B12 in the mitochondria

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In most people, the most common signs of a vitamin B12 deficiency may include fatigue, lethargy, pins and needles in the hands and feet, oral problems, confusion, and irritability

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doi:10.1016/j.cell.2017.03.014

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