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Inhibition of glucagon secretion or antagonism of glucagon receptors has become a potentially effective treatment strategy for T2DM patients (Lund et al., 2014)

Back Mojsov, S, Kopczynski, MG, Habener, JF (15 May 1990 )'Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas', Journal of Biological Chemistry , 265/14, 8001-8

The activated EPAC2 can further activate Ras protein 1 and phospholipase C, which activate the IP3 and diacylglycerol (DAG) pathways and promote the release of Ca 2+ (16)