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[234] [200] In addition to presynaptic actions that regulate DAT, TAAR1 activation exerts a somatodendritic inhibitory influence on midbrain dopamine neurons by reducing their firing rate via G protein-coupled inwardly-rectifying potassium channels, an effect that is expected to reduce action potential-dependent (vesicular) dopamine release into the synaptic cleft
By switching to a once-daily, modified-release formulation, Pfizer aims to reduce side effects and improve patient compliance
500 kg 550 kg 1 - 1 scoop once a day
The potential for drug-drug interaction with BYDUREON BCISE is expected to be similar to that of BYDUREON
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