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Shaking the vial is the number one peptide killer

However, in melanoma cell lines SK-MEL-147 and WM88, as well the glioblastoma cell line ONDA7, treatment with 2012 yielded low micromolar IC 50 values of 2.36, 4.42, and 9.79 M, respectively

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doi: 10.1016/j.cell.2019.07.047 143 NagataN.TohyaM.FukudaS.SudaW.NishijimaS.TakeuchiF.et al

Oral BPC-157 must survive the digestive tract, which is built to break peptide chains apart, so the two forms are generally discussed for different purposes

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