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Notably, CYP27B1 is also expressed in extra-renal tissues such as the placenta and prostate, where it facilitates local synthesis of 1,25(OH)D to modulate cellular functions via paracrine or autocrine signaling [96, 99]

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Drink alcohol or use prescription or over-the-counter medicines that contain alcohol

Disulfide bonds are relatively stable under physiological conditions but undergo selective cleavage in the tumor microenvironment (TME), minimizing premature drug release [53]