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The results deserve careful examination

3.10 Traumatic brain injury and stroke Traumatic brain injury (TBI) and ischemic stroke are common acute central nervous system injuries that share a characteristic cascade: following the initial mechanical or perfusion insult, mitochondrial dysfunction ensues, leading to excessive reactive oxygen species (ROS) production, calcium overload, and neuronal apoptosis

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10.1081/dmr-100104400 88 RaviV.CalumN

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(2018) using inducible pluripotent stem cells (iPSC)-derived neurons with triplication of SNCA gene showed that oligomeric -synuclein through inhibition of mitochondrial complex I activity caused oxidation of a subunit of ATP synthase leading to the opening of mitochondrial permeability transition pore with consequent mitochondrial swelling and cell death