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Interestingly, the previously unresolved region of DET1 spanning 7-11, which we named the claw, was found to bind to the backside of the Ube2e family members in the DDD-E2 complex (Supplementary Figs

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It is often called the master antioxidant because it protects every cell against free radicals, recycles other antioxidants, and supports detoxification processes

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In research models, inhibiting NNMT has been associated with preserved SAM and NAD availability, which is the mechanistic basis for studies into cellular energy and substrate handling