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People with certain medical conditions need extra caution

Revascularization is an effective strategy for salvaging ischemic myocardium in myocardial infarction [194, 195], while restoration of blood flow to the ischemic myocardium paradoxically exacerbates cardiac tissue damage, a phenomenon known as myocardial ischemiareperfusion (I/R) injury [196, 197]

However, the basis for the increased lactate and pyruvate, in some instances, may relate to non-mitochondrial processes such as glycolysis as is suggested by the absence of increased alanine and TCA intermediates noted in some other biomarker clusters (Figure 5, group 4)

doi: 10.1111/j.1600-0404.1999.tb07369.x [DOI] [PubMed] [Google Scholar] 64.Tourbah A, Lebrun-Frenay C, Edan G, Clanet M, Papeix C, Vukusic S, et al

* Who Needs Glutathione

Reece EM, Rohrich RJ